Systemic Manifestations of Invasive Amebiasis
Identifieur interne : 002E25 ( Main/Exploration ); précédent : 002E24; suivant : 002E26Systemic Manifestations of Invasive Amebiasis
Auteurs : M. Ahmed [Royaume-Uni] ; K. P. W. J. Mcadam [Royaume-Uni] ; A. W. Sturm [Royaume-Uni] ; R. Hussain [Royaume-Uni, Pakistan]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 1992.
Abstract
Eighty-four patients with serious infection due to Entamoeba histolytica were evaluated for systemic complications by objective criteria for dysfunction of the organ systems norma lly assessed in surgical sepsis. Of 71 patients with amebic liver abscess (ALA), 41% had systemic complications and 13% had more than one organ system involved. Patients ≥40 years of age and those being treated with steroids were at significantly increased risk of developing complications (P ≤ .05). The erythrocyte sedimentation rate and the levels of the acute-phase markers C-reactive protein (CRP) and serum amyloid A (SAA) were significantly elevated in patients with ALA over values in those without ALA (P ≤ .05). ALA patients with complications had lower CRP and SAA concentrations than those without complications (P ≤ .05). Blood and liver aspirates in ALA patients were usually bacteriologically sterile. The pathogenesis of systemic complications and the associated acute-phase response requires further study, and ways of predicting disease severity and intervening therapeutically must be devised.
Url:
DOI: 10.1093/clind/15.6.974
Affiliations:
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Ahmed</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Surgery and Microbiology, The Aga Khan University, Karachi, London, Pakistan</wicri:regionArea><wicri:noRegion>Pakistan</wicri:noRegion></affiliation></author><author><name sortKey="Mcadam, K P W J" sort="Mcadam, K P W J" uniqKey="Mcadam K" first="K. P. W. J." last="Mcadam">K. P. W. J. Mcadam</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Surgery and Microbiology, The Aga Khan University, Karachi, London, Pakistan</wicri:regionArea><wicri:noRegion>Pakistan</wicri:noRegion></affiliation></author><author><name sortKey="Sturm, A W" sort="Sturm, A W" uniqKey="Sturm A" first="A. W." last="Sturm">A. W. Sturm</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Surgery and Microbiology, The Aga Khan University, Karachi, London, Pakistan</wicri:regionArea><wicri:noRegion>Pakistan</wicri:noRegion></affiliation></author><author><name sortKey="Hussain, R" sort="Hussain, R" uniqKey="Hussain R" first="R." last="Hussain">R. Hussain</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Surgery and Microbiology, The Aga Khan University, Karachi, London, Pakistan</wicri:regionArea><wicri:noRegion>Pakistan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pakistan</country><wicri:regionArea>Reprints or correspondence: Dr. Rabia Hussain, Department of Microbiology, The Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800</wicri:regionArea><wicri:noRegion>Karachi 74800</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1992-12">1992</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="974">974</biblScope><biblScope unit="page" to="982">982</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Eighty-four patients with serious infection due to Entamoeba histolytica were evaluated for systemic complications by objective criteria for dysfunction of the organ systems norma lly assessed in surgical sepsis. Of 71 patients with amebic liver abscess (ALA), 41% had systemic complications and 13% had more than one organ system involved. Patients ≥40 years of age and those being treated with steroids were at significantly increased risk of developing complications (P ≤ .05). The erythrocyte sedimentation rate and the levels of the acute-phase markers C-reactive protein (CRP) and serum amyloid A (SAA) were significantly elevated in patients with ALA over values in those without ALA (P ≤ .05). ALA patients with complications had lower CRP and SAA concentrations than those without complications (P ≤ .05). Blood and liver aspirates in ALA patients were usually bacteriologically sterile. The pathogenesis of systemic complications and the associated acute-phase response requires further study, and ways of predicting disease severity and intervening therapeutically must be devised.</div></front></TEI><affiliations><list><country><li>Pakistan</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Ahmed, M" sort="Ahmed, M" uniqKey="Ahmed M" first="M." last="Ahmed">M. Ahmed</name></noRegion><name sortKey="Hussain, R" sort="Hussain, R" uniqKey="Hussain R" first="R." last="Hussain">R. Hussain</name><name sortKey="Mcadam, K P W J" sort="Mcadam, K P W J" uniqKey="Mcadam K" first="K. P. W. J." last="Mcadam">K. P. W. J. Mcadam</name><name sortKey="Sturm, A W" sort="Sturm, A W" uniqKey="Sturm A" first="A. W." last="Sturm">A. W. Sturm</name></country><country name="Pakistan"><noRegion><name sortKey="Hussain, R" sort="Hussain, R" uniqKey="Hussain R" first="R." last="Hussain">R. Hussain</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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